Weak association between HLA-DR4 and rheumatoid arthritis in Chilean patients

Article Abstract:

Rheumatoid arthritis (RA) is a joint disease characterized by inflammation of the joints, stiffness, swelling, overgrowth of cartilage tissue, and pain. Studies show that RA is associated with the presence of a histocompatibility antigen (HLA) called HLA-DR4. Histocompatibility antigens are genetic elements present on all cells with a nucleus, and are capable of activating the immune system. The relation between HLA-DR4 and RA is particularly evident among RA patients who are seropositive or who have indicators of RA in their blood, and varies with different ethnic groups. The prevalence of HLA-DR4 and HLA-DR9 was assessed in 64 Chilean patients with RA, and in 76 normal subjects. HLA-DR4 and HLA-DR9 were more prevalent among seropositive and seronegative RA patients than controls. However, when seronegative and seropositive RA patients were compared as separate groups with normal subjects, the prevalence of HLA-DR4 was similar, and was unrelated to the severity of disease. In contrast, the prevalence of HLA-DR9 was higher in seropositive RA patients compared with normal subjects. The results suggest that HLA-DR4 is a weak marker for RA, although RA is associated with the presence of another histocompatibility antigen, DR9. (Consumer Summary produced by Reliance Medical Information, Inc.)

Chile

---

Genes associated with rheumatoid arthritis and mild inflammatory arthritis: 1. major histocompatibility complex class I, II, and III allotypes

Article Abstract:

Rheumatoid arthritis (RA) is a joint disease characterized by inflammation of the joints, stiffness, swelling, overgrowth of cartilage tissue, and pain. The underlying causes of RA involve both genetic and environmental factors. RA has been associated with certain types of histocompatibility antigens (HLA), which are factors present on all cells with a nucleus and are controlled by the major histocompatibility gene complex (MHC). The prevalence of MHC antigens was assessed to determine whether patients with inflammatory arthritis were predisposed genetically to RA. The MHC antigens HLA-A24, A25, B27, B35, DR5, and C4A4 were higher in patients with inflammatory arthritis than in patients with RA. Patients with RA had abnormal levels of HLA-DR4, DR2 and related genetic components, consistent with results from other studies. The results show that the MHC antigens differ in inflammatory arthritis and RA, suggesting that these two joint disorders have different genetic characteristics. (Consumer Summary produced by Reliance Medical Information, Inc.)

Identification and classification, Arthritis

---

Influence of the HLA-DR-beta shared epitope on susceptibility to and clinical expression of rheumatoid arthritis in Chilean patients

Article Abstract:

There appears to be a moderate association between subsets of the genetic marker HLA-DRB and disease progression among Chilean patients with rheumatoid arthritis (RA). Genetic testing was performed on 129 Chilean patients with RA and 97 healthy Chilean volunteers (the control group). Fifty-four percent of the patients with RA carried both the DRB1*01 and DRB1*04 forms of the marker while only 30% of the control group did. Patients with two copies of the markers tended to have more advanced disease. However, 31% of the patients without two copies of the markers also had advanced disease.

Health aspects, HLA histocompatibility antigens

Similar abstracts:

• Abstracts: Listeria monocytogenes infection in a prosthetic knee joint in rheumatoid arthritis. Familial aggregation of undifferentiated spondylitis associated with HLA-B7
• Abstracts: Fish oil and rheumatoid arthritis: does a herring a day keep rheumatologists away? Effects of fish oil supplementation in rheumatoid arthritis
• Abstracts: Energy supplementation and the nutritional status of hemodialysis patients. Vitamin and trace element status of women with disordered eating
• Abstracts: Ascorbic acid protects lipids in human plasma and low-density-lipoprotein against oxidative damage. Physical training and copper, iron, and zinc status of swimmers

This website is not affiliated with document authors or copyright owners. This page is provided for informational purposes only. Unintentional errors are possible.