Epidemiologic evidence that prior antimicrobial exposure decreases resistance to infection by antimicrobial-sensitive Salmonella
Article Abstract:
Salmonella bacterial infections are a common cause of digestive illness, and can be fatal. These infections occur after the bacteria have grown in the human digestive tract, and many factors, such as age, acidity, and presence of normal intestinal bacteria, are known to alter this growth, or colonization. People who have been treated with antibiotics frequently develop infections of Salmonella bacteria that have become resistant to antibiotics because they have survived previous antibiotic treatment. A study of an outbreak of a specific strain of Salmonella, S. havana, which infected 72 people in Georgia in 1987, has shown that antibiotic treatment predisposed people to infections of antibiotic-sensitive, as well as resistant, strains of Salmonella. In contrast to antibiotic-resistant infections, which occur within 48 hours of antibiotic treatment (on average), antibiotic-sensitive infections occurred approximately 8 days following termination of antibiotic treatment. The results suggest that antibiotic-sensitive outbreaks of Salmonella may occur because the previous antibiotic treatment diminished the normal intestinal bacteria which normally provide resistance to Salmonella growth. Salmonella infections may occur in patients being treated for other infections, and may complicate treatment of such infections. (Consumer Summary produced by Reliance Medical Information, Inc.)
Publication Name: Journal of Infectious Diseases
Subject: Health
ISSN: 0022-1899
Year: 1990
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Yersinia enterocolitica O:3: an emerging cause of pediatric gastroenteritis in the United States
Article Abstract:
Yersinia enterocolitica is a bacterium that is known to be responsible for inflammation of the stomach and intestines, particularly in babies. In some countries the disease is endemic, and most often caused by a strain known as O:3. A major source of infection in these countries is pigs. The first reported outbreak of this strain in the Unites States occurred among black children in Atlanta and was attributed to contaminated pork intestines (chitterlings). To determine the prevalence of this illness in other black communities in the United States, a study was conducted at six hospitals in communities serving large black populations. Stool specimens from children diagnosed with gastroenteritis were cultured and analyzed. It was found that of 4,841 stool specimens collected, Y. enterocolitica was found in 38 samples, 92 percent of which were subtyped as O:3. Exposure to raw pork intestines within two weeks of infection was reported in 20 of the cases. It is suggested that Y. enterocolitica may be emerging as a significant illness in the United States. (Consumer Summary produced by Reliance Medical Information, Inc.)
Publication Name: Journal of Infectious Diseases
Subject: Health
ISSN: 0022-1899
Year: 1991
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