Synaptic plasticity: on the trail of the retrograde messenger
Article Abstract:
Long-term potentiation (LTP), the neurophysiological process in which high levels of activity stimulate increased synaptic transmission, is now known in greater detail. LTP occurs when high-frequency stimulation activates postsynaptic N-methyl-D-aspartate (NMDA) receptors followed by greater intracellular Ca2+ levels. However, arachidonic acid (AA) and nitric oxide (NO) have both been suggested as the chemicals responsible for effecting increased transmission following NMDA and Ca2+ activation. The truth may be that AA intensifies greater transmission levels brought on by NO.
Publication Name: Trends in Neurosciences
Subject: Psychology and mental health
ISSN: 0166-2236
Year: 1992
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Neurotransmitter regulation of neuronal outgrowth, plasticity and survival in the year 2001
Article Abstract:
Research on neurotransmitters has been extensive. However, several questions still remain. These questions deal with the source of neurotransmitters and how they are released from this source, the participation of neurotransmitters in the development and repair of neural circuits, and their contribution to neurologic disease. For instance, neurodegradation has been linked to increased Ca-super2+ concentrations. Ca-super2+ enters neurons through NMDA receptor controlled channels. Thus, development of NMDA-receptor antagonists can help control Ca-super2+ concentration build-up.
Publication Name: Trends in Neurosciences
Subject: Psychology and mental health
ISSN: 0166-2236
Year: 1995
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Models of neuronal injury in AIDS: another role for the NMDA receptor?
Article Abstract:
A study was done on the presence of immune-related toxins present in the brains of patients afflicted with AIDS. These toxins include the HIV coat protein gp120 and other toxic factors coming from the HIV-infected monocytoide cells. It was shown that a final common pathway for neuronal susceptibility exists which involves voltage-dependent calcium ion channels and N-methyl-D-aspartate receptor-operated channels.
Publication Name: Trends in Neurosciences
Subject: Psychology and mental health
ISSN: 0166-2236
Year: 1992
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