Suppression of programmed neuronal death by sustained elevation of cytoplasmic calcium
Article Abstract:
Almost half of vertebrate neurons die before reaching maturity due to a process called programmed cell death. Essential to the survival of neurons during this stage of development is the availability of certain neurotrophic substances. However, studies conducted in vitro reveal that chronic depolarization can take the place of these substances in enhancing neuronal survival by virtue of their ability to suppress programmed neuronal death. Evidence suggests that the rise of cytoplasmic free calcium through voltage-activated channels is responsible for mediating the effects of chronic depolarization.
Publication Name: Trends in Neurosciences
Subject: Psychology and mental health
ISSN: 0166-2236
Year: 1992
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Retinal regeneration
Article Abstract:
A study was done on retinal differentiation in fish using cellular transdifferentiation of the retinal pigment epithelium (RPE) and by proliferation of photoreceptor progenitors. It was shown that the RPE is not the source of regenerated retina in fish but its presence is important in the preservation of the integrity of the regenerated tissue. It was presumed that the RPE may be a possible source of growth factors in the process of retinal regeneration.
Publication Name: Trends in Neurosciences
Subject: Psychology and mental health
ISSN: 0166-2236
Year: 1992
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Neurons that say NO
Article Abstract:
A study was done on the nitric oxide (NO) transduction pathway in the nervous system. It was shown that the NO system is present in interneurons as well as neurons with long projections. Its activity is dependent on calcium ion concentration and acts mainly as an intercellular messenger. Increased intracellular calcium ion concentration needed to stimulate NO synthase activity was found to inhibit soluble guanylyl cyclase.
Publication Name: Trends in Neurosciences
Subject: Psychology and mental health
ISSN: 0166-2236
Year: 1992
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