Pore-forming segments in voltage-gated chloride channels
Article Abstract:
Research studies have located areas of the CIC isoform human skeletal muscle that contribute to anion-selective conduction pathway formation. An accessibility barrier between external and internal milieu is spanned by the CIC channel pore's core structural element, with the GKxGPxxH evolutionarily conserved sequence motif identified. Isoform-specific differences in anion selectivity are partly due to neighbouring fifth and third transmembrane segment sequences.
Publication Name: Nature
Subject: Zoology and wildlife conservation
ISSN: 0028-0836
Year: 1997
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Pore stoichiometry of a voltage-gated chloride channel
Article Abstract:
Research indicates that the Torpedo CIC-0 family chloride channel contains two aqueous permeation pathways, also described as pores. The human CIC-1 (hCIC-1) isoform, like many other ion channels investigated, has just one pore. Heterodimeric and homodimeric cysteine-substituted channel configurations are illustrated. Experiments using site-specific mutagenesis transient transfection and heterodimeric tandem construction on tsA201 cells are described.
Publication Name: Nature
Subject: Zoology and wildlife conservation
ISSN: 0028-0836
Year: 1998
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