A family of hyperpolarization-activated mammalian cation channels
Article Abstract:
A depolarizing, mixed Na+/K+ current, Ih, controls pacemaker activity of spontaneously active neurons. Ih also participates in the determination of the resting membrane potential of neurons. Ih is increased by hormones and neurotransmitters, via a mechanism independent of protein phosphorylation. The molecular cloning and function expression of the gene encoding a hyperpolarization-activated cation channel (HAC1) in the brain and heart, is reported. The channel shows the general properties of Ih channels.
Publication Name: Nature
Subject: Zoology and wildlife conservation
ISSN: 0028-0836
Year: 1998
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Interaction of glutamic-acid-rich proteins with the cGMP signalling pathway in rod photoreceptors
Article Abstract:
Glutamic-acid-rich proteins (GARPs) exist as GARP1 and GARP2, and as a large cytoplasmic domain of the beta-subunit of the cyclic GMP-gated channel. GARPs have been identified as multivalent proteins interacting with those involved in cGMP signalling, phosphodiesterase and guanylate cyclase, and with a retina-specific ATP-binding cassette transporter.
Publication Name: Nature
Subject: Zoology and wildlife conservation
ISSN: 0028-0836
Year: 1999
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