A new classification for HIV-1

Article Abstract:

HIV-1 isolates phenotypes can change in vivo, with significant implications for viral transmission, disease progression and pathogenesis. A new classification system is proposed, based on co-receptor use, giving more accurate descriptions of viral phenotype. There are currently three classification systems, defining primary isolates, categorizing isolates as syncytium-inducing or non-syncytium-inducing, and defining viruses as either slow/low or rapid/high. Isolates using CCR5, but not CXCR4 are termed R5 viruses in the new classification system, and isolates using CXCR4, but not CCR5, are designated X4 viruses.

HIV (Viruses), HIV, Viruses, Identification and classification, Virology

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Multiple essential functions of neuregulin in development

Article Abstract:

Neuregulin has been observed to function variedly in the the mutation processes. It helps spur growth and cell differentiation. In a study of the effects of the substance on mice, it was observed that embryos die during embryogenesis in the absence of a particular kind of neuregulin. Every cell type involved in the mutation was able to bind to erB3 and erB4, which are examples of tyrosine kinase receptors.

Genetic aspects, Mice, Mice (Rodents), Genetic regulation

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