A pore way to die
Article Abstract:
Cells die by an uncontrolled energy-independent process called necrosis that involves the opening of a pore in the inner mitochondrial membrane, known as the mitochondrial membrane permeability transition pore. The hypothesis show that the pore has three components, found in the inner of the two mitochondrial membranes, which normally, transports ATP out of the mitochondria, the voltage-dependent anion transporter in the outer mitochondrial membrane, and cyclophilin D.
Publication Name: Nature
Subject: Zoology and wildlife conservation
ISSN: 0028-0836
Year: 2005
User Contributions:
Comment about this article or add new information about this topic:
Mitochondrial dysfunction and oxidative stress in neurodegenerative diseases
Article Abstract:
Mitochondria are found to be key regulators of cell survival and death and they have a central role in ageing. They are also found to interact with many of the specific proteins implicated in genetic forms of neurodegenerative diseases. It is believed that therapies targeting basic mitochondrial processes such as energy metabolism or free-radical generation, or specific interactions of disease-related proteins with mitochondria hold great promise.
Publication Name: Nature
Subject: Zoology and wildlife conservation
ISSN: 0028-0836
Year: 2006
User Contributions:
Comment about this article or add new information about this topic:
- Abstracts: Drosophila pink1 is required for mitochondrial function and interacts genetically with parkin. Mitochondrial dysfunction in Drosophila PINK1 mutants in complemented by parkin
- Abstracts: Drosophila pink1 is required for mitochondrial function and interacts genetically with parkin. part 2 Pink, parkin and the brain
- Abstracts: Worker reproduction and social hierarchies in Leptothorax ants. Reproductive conflicts and mutilation in queenless Diacamma ants
- Abstracts: Name that tune: call discrimination and individual recognition in Magellanic penguins. Influence of vertical panels on use of space by domestic fowl
- Abstracts: Postfire Seeding for Erosion Control: Effectiveness and Impacts on Native Plant Communities