A receptor subtype involved in neuropeptide-Y-induced food intake
Article Abstract:
The Y5 receptor present in the hypothalamus of rat regulates the food intake induced by neuropeptide Y activity. High levels of Y5 mRNA are present in the paraventricular hypothalamic nucleus and lateral hypothalamus, and low levels in the testis. The localization of Y5 in the brain indicates that it regulates food intake by a postsynaptic method. Substances that increase food intake are strong Y5 agonists, while those that have no effect on feeding are weak agonists. The pharmacological profile and amino acid sequence of Y5 are different from that of other Y-type receptors.
Publication Name: Nature
Subject: Zoology and wildlife conservation
ISSN: 0028-0836
Year: 1996
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GABAB-receptor subtypes assemble into functional heteromeric complexes
Article Abstract:
Neurotransmitter GABA B-type receptors restrict neuronal activity. Drug efficiencies are shown to be different at different GABAB receptors, and it is likely that subtypes exists. GABAB-receptor splice variants were cloned and native GABAB receptors showed differences in agonist-binding potencies. A new GABAB receptor subtype, GABABR2 is described, which does not bind GABAB antagonists. Evidence is provided for the assembly of heteromeric GABAB receptors in vivo and GABABR2 and GABABR1a/b proteins are shown to immunoprecipitate and localize at dendritic spines.
Publication Name: Nature
Subject: Zoology and wildlife conservation
ISSN: 0028-0836
Year: 1998
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GABAB receptors function as a heteromeric assembly of the subunits GABABR1 and GABABR2
Article Abstract:
The main inhibitory neurotransmitter GABA operates via two ligand-gated channels GABAA and GABAC receptors, and GABAB, a receptor. GABABR2 is a new member of the GABAB polypeptide group, and has a sequence homology to GABABR1. GIRK-type potassium channels are not activated when GABABR1 or GABAR2 are expressed individually. Both are co-expressed in individual neurons and they co-localize in transfected cells. Their co-expression is required for signal transduction by GABAB receptors.
Publication Name: Nature
Subject: Zoology and wildlife conservation
ISSN: 0028-0836
Year: 1998
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