A sense of something missing
Article Abstract:
The hypothesis that the lysing of tumor cells by natural killer (NK) cells is impaired when the NK receptor Ly-49 is involved with major histocompatibility complex (MHC) class I molecules on the target cell received new support from research results by F.M. Karlhofer and colleagues. They ascertained Ly-49's role by testing Ly-49+ and Ly-49- on several tumor target cells; MHC genotype was strongly correlated with the effect of Ly-49+ on the tumor cells. In addition, W. Storkus and colleagues found that the peptide-binding groove of class I MHC molecules is involved in recognition by NK cells.
Publication Name: Nature
Subject: Zoology and wildlife conservation
ISSN: 0028-0836
Year: 1992
User Contributions:
Comment about this article or add new information about this topic:
Allelic exclusion of Ly49-family genes encoding class I MHC-specific receptors on NK cells
Article Abstract:
Allelic exclusion of Ly49 genes probably involves a mechanism that is different from that used by B and T lymphocytes and may play an important role in the genesis of a putative natural killer (NK)-cell receptor that is specific for class I molecules. NK-cell activity causes lysis of cells that stop expression of all or some of Class I major histocompatibility (MHC) molecules. Ly49A and Ly49C expression have a specificity for MHC and they are subject to allelic exclusion by NK-cell receptors.
Publication Name: Nature
Subject: Zoology and wildlife conservation
ISSN: 0028-0836
Year: 1995
User Contributions:
Comment about this article or add new information about this topic:
Selection is not required to produce invariant T-cell receptor gamma-gene junctional sequences
Article Abstract:
The hypothesis that thymic selection operating on a population of originally diverse progenitor cells contributes to invariant junctional sequences in T-cell antigen receptors (TCR) was tested. Mutated TCR gamma-gene rearrangement substrates were intorduced into mice as transgenes. The results indicate that the canonical TCR Vgamma3-Jgamma1 and Vgamma4-Jgamma1 sequences occur at high frequency in the absence of the possibility selection for the protein products.
Publication Name: Nature
Subject: Zoology and wildlife conservation
ISSN: 0028-0836
Year: 1993
User Contributions:
Comment about this article or add new information about this topic:
- Abstracts: Effect of including relationships in the estimation of genetic parameters of beef calves. Estimates of repeatability and heritability of horn fly resistance in beef cattle
- Abstracts: Conveying that sinking feeling. Warming of the tropical Atlantic Ocean and slowdown of thermohaline circulation during the last deglaciation
- Abstracts: Effects of lamb age, muscle type, and 24-hour activity of endogenous proteinases on postmortem proteolysis. The effect of postmortem time of injection and freezing on the effectiveness of calcium chloride for improving beef tenderness
- Abstracts: Oldest known fossils of monocotyledons. Three-dimensional preservation of algae and animal embryos in a Neoproterozoic phosphorite
- Abstracts: Synthesis of cadmium sulphide superlattices using self-assembled bacterial-S-layers. Bacteria and the Midas touch