A var gene promoter controls allelic exclusion of virulence genes in Plasmodium falciparum malaria
Article Abstract:
A var promoter mediates the nucleation and spreading of stably inherited silenced chromatin in the malarial parasite Plasmodium falciparum. Transcriptional activation of the promoter occurs at the nuclear periphery in association with chromosome-end clusters and the var promoter sequence is sufficient to infiltrate a transgene into an allelic exclusion program of var gene expression, resulting in mono-allelic transcription of the virulence gene family.
Publication Name: Nature
Subject: Zoology and wildlife conservation
ISSN: 0028-0836
Year: 2006
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Pgh1 modulates sensitivity and resistance to multiple antimalarials in Plasmodium falciparum
Article Abstract:
The development and spread of resistance to many front-line antimalarial compounds has caused concern. Polymorphisms in pfmdr1 have been linked to chloroquine resistance, and Pgh1 has been linked to mefloquine and halofantrine resistance. Proof is provided that mutations in Pgh1 can confer resistance to mefloquine, quinine and halofantrine, with important implications for the development of future antimalarial compounds.
Publication Name: Nature
Subject: Zoology and wildlife conservation
ISSN: 0028-0836
Year: 2000
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Sodium-dependent uptake of inorganic phosphate by the intracellular malaria parasite
Article Abstract:
The malaria parasite Plasmodium falciparum exploits the [Na.sup.+] electrochemical gradient to energize the uptake of inorganic phosphate ([P.sub.1]), an essential nutrient. It provides a new insight into the significance of the malaria-parasite-induced alteration of the ionic composition of its host cell.
Publication Name: Nature
Subject: Zoology and wildlife conservation
ISSN: 0028-0836
Year: 2006
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