Functional link between ataxia-telangiectasia and Nijmegen breakage syndrome gene products
Article Abstract:
It has been possible to identify two residues of Nijmegen breakage syndrome (NBS)-1, Ser 278 and Ser 343, that are phosphorylated in vitro by ATM, the protein product of the gene responsible for ataxia-telangiectasia. The modification in vivo of these residues is vital for the cellular response to DNA damage.
Publication Name: Nature
Subject: Zoology and wildlife conservation
ISSN: 0028-0836
Year: 2000
User Contributions:
Comment about this article or add new information about this topic:
ATM phosphorylation of Nijmegen breakage syndrome protein is required in a DNA damage response
Article Abstract:
Research into Nijmegen breakage syndrome is presented. It has been established that Nbs is specifically phosphorylated in response to gamma-radiation, ultraviolet light and exposure to hydroxyurea. Phosphorylation of Nbs by the ataxia telangiectasia mutated gene is vital for certain responses of human cells to DNA damage.
Publication Name: Nature
Subject: Zoology and wildlife conservation
ISSN: 0028-0836
Year: 2000
User Contributions:
Comment about this article or add new information about this topic:
Crossing over to drug resistance
Article Abstract:
The chemotherapeutic drug resistance mechanism and the action of drugs that are used for the treatment of breast and ovarian cancers are investigated. The drug resistance is found to develop on the restoration of homologous recombination (HR), a DNA-damage repair pathway.
Publication Name: Nature
Subject: Zoology and wildlife conservation
ISSN: 0028-0836
Year: 2008
User Contributions:
Comment about this article or add new information about this topic:
- Abstracts: A comprehensive analysis of protein-protein interactions in Saccharomyces cerevisiae. Genome sequencing in microfabricated high-density picolitre reactors
- Abstracts: Structure of the winged-helix protein hRFX1 reveals a new mode of DNA binding. Crystal structure of TFIID TATA-box binding protein
- Abstracts: Discovery of a new population of high-energy gamma-ray sources in the Milky Way. Pulsed high-energy gamma-rays from the radio pulsar PSR1706-44
- Abstracts: Imaging of localized electronic states in the quantum Hall regime. Four-terminal resistance of a ballistic quantum wire
- Abstracts: Comparative habitat use by three quails in desert grassland. Comparative habitat ecology of Texas and masked bobwhites