Adhesion articulated

Article Abstract:

The vertical extension that enables molecules to rise to the task of mediating cell adhesion is explained by a new structure of the head region of an integrin protein. The intramolecular signal transduction for one particular integrin termed alpha(sub IIb)beta3, which is found on platelets and binds to the blood protein fibrinogen helps to know the core mechanism that controls cellular adhesiveness.

United States, Integrins, Blood proteins

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Direct observation of catch bonds involving cell-adhesion molecules

Article Abstract:

Atomic force microscopy and flow-chamber experiments are used to show that increasing force first prolonged and then shortened the lifetimes of P-selection complexes with P-selection glycoprotein ligand-1 to reveal both catch and slip bond behavior.

Leukocytes, White blood cells

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The molecular architecture of cadherins in native epidermal desmosomes

Article Abstract:

The three-dimensional molecular architecture of cadherins present in native epidermal desmosomes junctions in a human body is discussed.

Technology application, Structure, X-ray analysis, Desmosomes

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