Persistent DDT metabolite p,p'-DDE is a potent androgen receptor antagonist
Article Abstract:
The DDT metabolite p,p'-DDE is responsible for the antagonistic effects of DDT on the male reproductive system and is due to the restraining of the androgen receptor (AR)-androgen binding followed by inhibition of transcriptional activity. A mammary tumor promoter-luciferase reporter vector of mouse and monkey kidney CV1 cells with the human AR expression vector were used to study p,p'-DDE's androgen action-blocking ability at the AR level using transient cotransfection. In vivo antiandrogenic effects occurred most likely because the p,p'-DDE can cross the placenta to the developing fetus in rats.
Publication Name: Nature
Subject: Zoology and wildlife conservation
ISSN: 0028-0836
Year: 1995
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A role for oestrogens in the male reproductive system
Article Abstract:
Research shows that oestrogen plays a physiological role in male reproductive organs, with oestrogen shown to regulate luminal fluid reabsorption in the epididymis head. Infertility occurs when the vital function is disrupted and diluted sperm enters the epididymis. Environmental oestrogens may potentially have an adverse impact on male reproduction. Testosterone and oestrogen are both present in males and females, with male concentrations of oestrogen very high in semen but low in blood.
Publication Name: Nature
Subject: Zoology and wildlife conservation
ISSN: 0028-0836
Year: 1997
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