Asymmetric and symmetric stem-cell divisions in development and cancer
Article Abstract:
An attempt is made to explore the idea that most stem cells can divide by either asymmetric or symmetric modes of division, and that the balance between these two modes is controlled by developmental and environmental signals to produce appropriate numbers of stem cells and differentiated daughters. Increased use of symmetric divisions by stem cells result in higher incidence of cancer given the circumstantial evidences that cancer frequently arises from the transformation somatic stem cells.
Publication Name: Nature
Subject: Zoology and wildlife conservation
ISSN: 0028-0836
Year: 2006
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Fusion of bone-marrow-derived cells with Purkinje neurons, cardiomyocytes and hepatocytes
Article Abstract:
Bone-marrow derived cells (BMDCs) fuse spontaneously with neural progenitors in vitro is demonstrated. Bone-marrow transplantation showed that BMDCs fuse in vivo with hepatocytes in liver, Purkinje neurons in the brain and cardiac muscles in the heart, resulting multi-nucleated cells formation.
Publication Name: Nature
Subject: Zoology and wildlife conservation
ISSN: 0028-0836
Year: 2003
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Unique astrocyte ribbon in adult human brain contains neural stem cells but lacks chain migration
Article Abstract:
The subventricular zone (SVZ) is a principal source of adult neural stem cells in the rodent brain. A ribbon of SVZ astrocytes which line the lateral ventricles of the adult human brain is presented that proliferate in vivo and behave as multipotent progenitor cells in vitro.
Publication Name: Nature
Subject: Zoology and wildlife conservation
ISSN: 0028-0836
Year: 2004
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