Binding and modulation of p53 by p300/CBP coactivators
Article Abstract:
Research suggests P300/CBP transcriptional coactivators act as transcriptional adaptors for the tumour suppressor p53. P300/CBP binds to p53 where there are no viral oncoproteins, with both p53 and p300 coexisting in a DNA-binding complex. Adenovirus E1A oncoproteins suppressed the apoptosis and cell-cycle arrest induced by p53 while lowering the activation of bax and p21 promoters mediated by p53. E1A may induce cell transformation by disrupting growth control which is p300/p53-dependent.
Publication Name: Nature
Subject: Zoology and wildlife conservation
ISSN: 0028-0836
Year: 1997
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Mdm2 promotes the rapid degradation of p53
Article Abstract:
The Mdm2 oncoprotein is found to be effective in controlling the antiproliferative effects, particularly apoptosis and growth arrest, of the p53 tumor-suppressor protein. This is attained by blocking the regulatory capabilities and binding the transcriptional activation domain of p53. In addition, the accumulation of mutant p53s in tumor-derived cells is repressed. These factors can be used to develop a mechanism for terminating the p53 signal.
Publication Name: Nature
Subject: Zoology and wildlife conservation
ISSN: 0028-0836
Year: 1997
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Poll gets repressed
Article Abstract:
A new mechanism has been discovered for Rb-mediated growth suppression. The Rb, a retioblastoma gene products is essential in transcriptional regulation during the cell cycle. The Rb is a tumor suppressor element. The new mechanism involves the inhibition of the transcription activation of RNA polymerase I by the Rb.
Publication Name: Nature
Subject: Zoology and wildlife conservation
ISSN: 0028-0836
Year: 1995
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