Biospecific interaction analysis using biosensor technology
Article Abstract:
BIAcore is a new biomolecular analytical system using biosensor technology. The system allows researchers to examine how proteins, DNA, ligands and receptors react to each other by immobilizing and measuring the molecules. Biosensors permit the uptake of biomolecules to be carefully regulated. The new system has been used to study kinetics, kinetic analysis of monoclonal antibody binding, epitope mapping, recombinant antibodies and, most recently, HIV interactions. BIAcore, produced by Pharmacia Biosensor AB of Uppsala, Sweden, is also being used for pharmaceutical research and quality control.
Publication Name: Nature
Subject: Zoology and wildlife conservation
ISSN: 0028-0836
Year: 1993
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A kinase-regulated PDZ-domain interaction controls endocytic sorting of the beta-2-adrenergic receptor
Article Abstract:
It has been established that sorting of internalized beta-2-adrenergic receptors (ARs) between recycling and degradative endocytic pathways is controlled by a protein interaction involving the distal carboxyl-terminal cytoplasmic domain of the beta-2-AR. It is suggested that this sorting operation is controlled by PDZ-mediated interaction of the beta-2-AR with ezrin-radixin-moesin-binding phosphoprotein-50/NHERF family proteins. This research has provided evidence for a role for PDZ domains and the cortical cytoskeleton in regulating the sorting of receptors following endocytosis.
Publication Name: Nature
Subject: Zoology and wildlife conservation
ISSN: 0028-0836
Year: 1999
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A biosensor that uses ion-channel switches
Article Abstract:
There are many different potential applications for a biosensing technique in which the conductance of a population of molecular ion channels is switched by the recognition event. These could include cell typing and the detection of DNA, electrolytes and viruses. The biosensor can operate in plasma, human serum and whole blood, and can be used on electrodes with a wide range of dimensions. Its sensitivity can be boosted by operating it under conditions of low channel density.
Publication Name: Nature
Subject: Zoology and wildlife conservation
ISSN: 0028-0836
Year: 1997
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