Calcium activation of Ras mediated by neuronal exchange factor Ras-GRF
Article Abstract:
Ras in vivo appears to activate in response to neuronal exchange factor Ras-GRF's exposure to Ca2+ as well as activating through the accepted tyrosine kinase receptor pathway. The activation link to Ca2+ indicates that Ras-GRF may be involved in the regulation of Ca2+ influenced neuronal functions. Calmodulin appears responsible for mediating Ras activation through binding to an IQ motif.
Publication Name: Nature
Subject: Zoology and wildlife conservation
ISSN: 0028-0836
Year: 1995
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BAD and glucokinase reside in a mitochondrial complex that integrates glycolysis and apoptosis
Article Abstract:
The pro-apoptotic BCL-2 family protein BAD is essential for the assembly of a functional holoenzyme complex along with protein kinase A and protein phosphatase 1 and two other proteins. Research shows that BAD mediates the regulation of glucokinase activity as well. Together, data indicate that BAD integrates pathways of glucose metabolism and apoptosis.
Publication Name: Nature
Subject: Zoology and wildlife conservation
ISSN: 0028-0836
Year: 2003
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Towards a molecular understanding of adaptive thermogenesis
Article Abstract:
Adaptive thermogensis is attracting more and more attention as a target for the development of antiobesity therapies. Basic research must still address a number of questions, including the identity of the dominant thermogenic mechanisms in human muscle.
Publication Name: Nature
Subject: Zoology and wildlife conservation
ISSN: 0028-0836
Year: 2000
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