Calreticulin is essential for integrin-mediated calcium signalling and cell adhesion
Article Abstract:
The cytoplasmic areas of integrins, which are important mediators of cell adhesion, have a role in the regulation of cell shape, growth, motility and differentiation. The development of calreticulin-deficient embryonic stem cells and isolated embryonic fibroblasts from calreticulin mutant mice is described. Integrin-mediated adhesion was found to be severely impaired and cytosolic calcium was absent from calreticulin-deficient cells. This indicates that calreticulin is essential in the modulation of both integrin adhesive functions and integrin signalling.
Publication Name: Nature
Subject: Zoology and wildlife conservation
ISSN: 0028-0836
Year: 1997
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The viral mousetrap
Article Abstract:
Two separate research projects have identified similarities between the core structure of the transmembrane glycoprotein gp41 and the influenza-virus HA2 protein. This protein forms the basis for viral fusion mechanisms. This finding has significance for research into AIDS and the ways in which human immuno-deficiency virus fuses with cells. It is now acknowledged that understanding of the native structure of the HIV-1 envelope must be improved. Structural studies may play a key role in helping to find ways to stop HIV-cell fusion.
Publication Name: Nature
Subject: Zoology and wildlife conservation
ISSN: 0028-0836
Year: 1997
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A better mousetrap
Article Abstract:
The article discusses the struggle of the scientists at the Heisenberg Space Station to get rid of the mouse present in their laboratory, which ultimately led to the development of a better mousetrap.
Publication Name: Nature
Subject: Zoology and wildlife conservation
ISSN: 0028-0836
Year: 2007
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