Cbl-b regulates the CD28 dependence of T-cell activation
Article Abstract:
Deficiency of the adaptor molecule Cbl-b leads to impaired CD28 surveillance on T-cell activation. This is, at least partially, responsible for the raised susceptibility of mutant mice to autoimmune diseases. It was established that Cbl-b does not have a significant impact on the main T-cell antigen receptor (TCR) signalling pathways, while loss of Cbl-b correlates with Vav activation. It is possible that Cbl-b affects the CD28 dependence of T-cell activation by selectively suppressing TCR-mediated Vav activation.
Publication Name: Nature
Subject: Zoology and wildlife conservation
ISSN: 0028-0836
Year: 2000
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Long-term acceptance of skin and cardiac allografts after blocking CD40 and CD28 pathways
Article Abstract:
The simultaneous blockade of the CD28 and CD40 pathways prevents rejection of skin and cardiac allografts and encourages their long-term acceptance by suppressing T-cell clonal expansion in vitro and in vivo. The blockade suppresses the immune responses that are controled by the T-cells. Inhibition of only one pathway is insufficient to prevent graft rejection. This shows that the paths are related to each other but function independently.
Publication Name: Nature
Subject: Zoology and wildlife conservation
ISSN: 0028-0836
Year: 1996
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Decoy receptors thwart B cells
Article Abstract:
Two receptors for the protein, BAFF, implicated in lupus erythematosus, have been identified.
Publication Name: Nature
Subject: Zoology and wildlife conservation
ISSN: 0028-0836
Year: 2000
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