Cellular mechanism for anti-analgesic action of agonists of the kappa-opioid receptor
Article Abstract:
The analgesic effect of opioids primarily activates the mu-opioid receptor but has a similar effect on the kappa-receptor, whose role is less clear. While kappa-receptors produce analgesia, they are also found to antagonize morphine analgesia. New research shows that the activation of the kappa-receptor specifically antagonizes analgesia induced by the mu-receptor. The finding suggest new approaches to the treatment of opioid addiction and pain control.
Publication Name: Nature
Subject: Zoology and wildlife conservation
ISSN: 0028-0836
Year: 1997
User Contributions:
Comment about this article or add new information about this topic:
The rise of neurogenetic determinism
Article Abstract:
Reductionist interpretations of advances in neuroscience hamper the application of available neuroscientific knowledge in human interests. Neuroscientific advances have improved the perception of brain and behavior and possess the potential to attenuate human suffering. Hence, an unidirectional understanding of these advances should be replaced with integrated understanding of the relationship between biological, personal and social issues.
Publication Name: Nature
Subject: Zoology and wildlife conservation
ISSN: 0028-0836
Year: 1995
User Contributions:
Comment about this article or add new information about this topic:
- Abstracts: Molecular basis of agonism and antagonism in the oestrogen receptor. Crystal structure of an NK cell immunoglobulin-like receptor in complex with its class I MHC ligand
- Abstracts: Sites of alcohol and volatile anaesthetic action on GABA and glycine receptors. LTRPC7 is a Mg.ATP-regulated divalent cation channel required for cell viability
- Abstracts: An earthquake mechanism based on rapid sealing of faults. No need to stick to the point. The dating of shallow faults in the Earth's crust
- Abstracts: Like-charge attractions in metastable colloidal crystallites. Ultradivided matter
- Abstracts: Locally layered convection inferred from dynamic models of the Earth's mantle