Co-crystal structure of the HNF-3/fork head DNA-recognition motif resembles histone H5
Article Abstract:
The transcription factor fold of the co-crystal structure of the HNF-3/fork head DNA-recognition motif resembles histone H5. The structure was determined by X-ray crystallography at 2.5 angstrom resolution. Through direct and water-mediated major and minor groove base contacts the protein binds beta-DNA as a monomer, inducing a 13 degree bend. Three alpha-helices adopt a compact structure that binds the third helix to the major groove while a twisted, antiparallel beta-structure that interacts with the minor groove makes up the rest of the protein.
Publication Name: Nature
Subject: Zoology and wildlife conservation
ISSN: 0028-0836
Year: 1993
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Differential effects of the Rac GTPase on Purkinje cell axons and dendritic trunks and spines
Article Abstract:
A study was conducted to determine Rac1 activity perturbations on the growth of axons and dendrites. Transgenic mice expressing constitutively active human Rac1 in Purkinje cells were found to be ataxic and have a reduction of Purkinje-cell axon terminals in the deep cerebellar nuclei. Results suggest specific mechanisms for the elaboration of axons, dendrites and dendritic spines, based on differential effects of perturbing Rac1 activity.
Publication Name: Nature
Subject: Zoology and wildlife conservation
ISSN: 0028-0836
Year: 1996
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A new factor related to TATA-binding protein has highly restricted expression patterns in Drosophila
Article Abstract:
A DNA-binding Drosophila gene product related to the TATA-binding protein (TBP) has been cloned and characterized. The TBP-related factor has considerable sequence similarity to TBP and is not likely to to be a basal transcription factor. Evidence suggests that the factor has the DNA-binding properties of TBP and is a sequence-specific transcription factor. TBP has been shown to play an important role in eukaryotic gene transcription.
Publication Name: Nature
Subject: Zoology and wildlife conservation
ISSN: 0028-0836
Year: 1993
User Contributions:
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