Bax-independent inhibition of apoptosis by Bcl-x(sub l)
Article Abstract:
Interaction with Bax is unnecessary for Bcl-x(sub l) to inhibit apoptosis. Mutations of residues in Bcl-x(sub l), that bind to Bax or Bak, reduce its inhibitory activity to a small extent. Site-specific mutagenesis indicate that the amino acids required for the suppression of Sindbis virus-induced cell death by Bcl-x(sub l) are in the Bcl-2-homology regions 1 and 2. The amino acids necessary for the Bcl-x(sub l) activity are different from those necessary for Bcl-2 function.
Publication Name: Nature
Subject: Zoology and wildlife conservation
ISSN: 0028-0836
Year: 1996
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X-linked IAP is a direct inhibitor of cell-death proteases
Article Abstract:
A recombinant XIAP protein and a cell free system was used to investigate human X-chromosome-linked inhibitor-of-apoptosis (IAP). IAP genes are important in regulating programme cell death in animals. Cell death can be suppressed by ectopic expression of human IAP proteins. The human X-chromosome linked IAP was found to directly inhibit cell death proteases caspase.
Publication Name: Nature
Subject: Zoology and wildlife conservation
ISSN: 0028-0836
Year: 1997
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- Abstracts: Conversion of lytic to persistent alphavirus infection by the bcl-2 cellular oncogene. Bcl-2 blocks apoptosis in cells lacking mitochondrial DNA
- Abstracts: Age pigment structure. The red sweat of the hippopotamus: the red and orange pigments in this secretion account for its protective properties