Copy number polymorphism in Fcgr3 predisposes to glomerulonephritis in rats and humans
Article Abstract:
Copy number variation of the orthologous rat and human Fcgr3 genes is a determinant of susceptibility to immunologically mediated glomerulonephritis. Positional cloning identifies loss of the rat-specific Fcgr3 paralogue, Fcgr3-related sequence as a determinant of macrophage overactivity and glomerulonephritis in Wistar Kyoto rats and in humans, low copy number of FCGR3B, is associated with glomerulonephritis in the autoimmune disease systemic lupus erythematosus.
Publication Name: Nature
Subject: Zoology and wildlife conservation
ISSN: 0028-0836
Year: 2006
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Molecular analysis of the association of HLA-B53 and resistance to severe malaria
Article Abstract:
The human leukocyte antigen-B53 (HLA-B53) bolsters immunological defenses against the acute form of malaria caused by the parasite Plasmodium falciparum (P. falciparum). Research involving malaria-resistant Africans found that HLA-B53 assisted the cytotoxic T lymphocytes in attacking P. falciparum during the pre-erythrocytic phase of the parasite's life-cycle which occurs in the liver. HLA-B53 may eventually become a key part of a future antimalarial vaccine.
Publication Name: Nature
Subject: Zoology and wildlife conservation
ISSN: 0028-0836
Year: 1992
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Malaria susceptibility and CD36 mutation
Article Abstract:
Research is presented concerning the susceptibility of people of African origin to infection by Plasmodium falciparum which causes the severest form of malaria. The connection between CD36 mutation and susceptibility to the disease is discussed.
Publication Name: Nature
Subject: Zoology and wildlife conservation
ISSN: 0028-0836
Year: 2000
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