Crystal structure of the nucleosome core particle at 2.8 A resolution
Article Abstract:
Researchers have solved the high resolution X-ray structure of the nucleosome core particle. The crystal structure of the nucleosome core particle of chromatin includes a 146 base pair DNA molecule. The atomic model shows these pairs in a superhelix around the histone protein octamer. Each histone contains a histone fold domain and there are well-ordered structure elements extending from the histone motif. These two aspects determine the histone/histone and histone/DNA interactions. The DNA differs from ideal superhelix geometry due to the lack of uniformity in these interactions.
Publication Name: Nature
Subject: Zoology and wildlife conservation
ISSN: 0028-0836
Year: 1997
User Contributions:
Comment about this article or add new information about this topic:
Chromatin remodeling at a DNA double-strand break site in Saccharomyces cerevisiae
Article Abstract:
Chromatin structure is altered in response to double-strand breaks (DSBs) and such alterations influence DSB repair processes. MRX regulates two pathways of chromatin changes such as nucleosome displacement for efficient recruitment of homologous recombination proteins and phosphorylation of H2A modulates checkpoint responses to DNA damage.
Publication Name: Nature
Subject: Zoology and wildlife conservation
ISSN: 0028-0836
Year: 2005
User Contributions:
Comment about this article or add new information about this topic:
Structural determinants for generating centromeric chromatin
Article Abstract:
A study conducted reveals that the centromeric protein A (CENP-A) and histone H4 form sub-nucleosomal tetramers that are more compact and conformationally more rigid than the corresponding tetramers of histones H3 and H4. The analysis was done using deuterium exchange/mass spectrometry coupled with hydrodynamic measures.
Publication Name: Nature
Subject: Zoology and wildlife conservation
ISSN: 0028-0836
Year: 2004
User Contributions:
Comment about this article or add new information about this topic:
- Abstracts: Crystal structure of RecBCD enzyme reveals a machine for processing DNA breaks. RecBCD enzyme is a bipolar DNA helicase
- Abstracts: Structure of the conserved GTPase domain of the signal recognition particle. Substrate twinning activates the signal recognition particle and its receptor
- Abstracts: Structure of the yeast polarity protein Sro7 reveals a SNARE regulatory mechanism. How to build a cell junction
- Abstracts: Stabilization of microtubule dynamics at anaphase onset promotes chromosome segregation. Separase-mediated cleavage of cohesin at interphase is required for DNA repair