Cytotoxic T-cell immunity to virus-infected non-haematopoietic cells requires presentation of exogenous antigen
Article Abstract:
Research designed to establish whether non-haematopoietic cells can act as antigen-presenting cells (APCs) to initiate cytotoxic T lymphocyte (CTL) responses to viruses has involved constructing bone-marrow chimaeras by lethally irradiating C57Bl/6 mice and reconstituting them with bone marrow from TAP0/0 mice. It was not possible to specifically determine the identity of the bone-marrow-derived APCs responsible for prompting CTL responses through the exogenous pathway, but it seems that macrophages and/or dendritic cells are likely to be responsible. It is clear that the exogenous pathway plays a significant role in the immune surveillance of non-haematopoietic tissues.
Publication Name: Nature
Subject: Zoology and wildlife conservation
ISSN: 0028-0836
Year: 1999
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A role for the ubiquitin-dependent proteolytic pathway in MHC class I-restricted antigen presentation
Article Abstract:
Proteolytic pathways rely on the conjugation of ubiquitin with the protein to be degraded. Some antigenic peptides are also produced in the cytosol which bind with class I complexes and have the same labelling function for recognition by the degradative particle called the proteasome. Experiments with ovalbumin introduced into the cytosol show that ovalbumin must be conjugated with ubiquitin to generate antigenic peptides. This study will be helpful in recognition of certain virus peptides and the pathway for antigen action.
Publication Name: Nature
Subject: Zoology and wildlife conservation
ISSN: 0028-0836
Year: 1993
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Identification of the gal4 suppressor Sug1 as a subunit of the yeast 26S proteasome
Article Abstract:
The Sug1 gene of Saccharomyces cerevisiae is an integral component of the yeast 26S proteasome. Sug1 co-precipitates with proteasome in conventional and nickel-chelate affinity chromatography. The 26S proteasome catalyzes the ATP-dependent degradation of ubiquitin-protein conjugate. Defective proteolysis regulates the effect of Sug1 mutation on transcription.
Publication Name: Nature
Subject: Zoology and wildlife conservation
ISSN: 0028-0836
Year: 1996
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