DNA synthesis provides the driving force to accelerate DNA unwinding by a helicase
Article Abstract:
A report of T7 DNA polymerase is presented, which is unable to catalyze strand displacement DNA synthesis by itself, but is able to increase the unwinding rate to 114 base pairs per second, bringing the helicase up to similar speeds compared to its translocation along single stranded DNA (ssDNA). It is found that the helicase rate of stimulation depends upon the DNA synthesis rate.
Publication Name: Nature
Subject: Zoology and wildlife conservation
ISSN: 0028-0836
Year: 2005
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8-Oxo-guanine bypass by human DNA polymerases in the presence of auxiliary proteins
Article Abstract:
The effects of human proliferating cell nuclear antigen (PCNA) and replication protein A (RP-A) on six different human DNA pols, during in vitro bypass of different lesions are examined. The results show the existence of an accurate mechanism to reduce the deleterious consequences of oxidative damage.
Publication Name: Nature
Subject: Zoology and wildlife conservation
ISSN: 0028-0836
Year: 2007
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Error-prone replication of oxidatively damaged DNA by a high-fidelity DNA polymerase
Article Abstract:
The sequential snapshots of a high-fidelity DNA polymerase during both accurate and mutagenic replication of 8oxoG are presented. These crystals when compared revealed that 8oxoG induces an inversion of the mismatch recognition mechanisms that normally proofread DNA.
Publication Name: Nature
Subject: Zoology and wildlife conservation
ISSN: 0028-0836
Year: 2004
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