Deregulated cyclin E induces chromosome instability
Article Abstract:
It has been established that deregulation of cyclin-E/Cdk2 kinase activity can have an impact on the fidelity of chromosome transmission in mammalian cells. This finding emphasizes the significance of changes in cyclin E as an early stage in the genesis of some tumours, as well as its role in tumour progression. It was found that constitutive cyclin-E overexpression in both immortalized rat embryo fibroblasts and human breast epithelial cells leads to chromosome instability. The frequency of chromosome instability is not increased by analogous expression of cycling D1 or A.
Publication Name: Nature
Subject: Zoology and wildlife conservation
ISSN: 0028-0836
Year: 1999
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Evidence that a free-running oscillator drives G1 events in the budding yeast cell cycle
Article Abstract:
Recent research supports a model for the budding yeast cell cycle in which G1 events are sparked off by a G1 cyclin/mitotic cyclin-independent cell-cycle oscillator in normal cycling cells. It was possible to identify a role for B-type cyclin-associated kinase in stopping the initiation of new G1 events during checkpoint arrests. It is suggested that, in yeast, the activity of B-type cyclin-associated kinase attenuates the activity or outputs of the independent oscillator when cell-cycle progression cannot take place and checkpoints are activated.
Publication Name: Nature
Subject: Zoology and wildlife conservation
ISSN: 0028-0836
Year: 1999
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Human F-box protein hCdc4 targets cyclin E for proteolysis and is mutated in a breast cancer cell line
Article Abstract:
Research is presented concerning the influence of cyclin E on the initiation of S-phase functions and DNA replication. The mutation of the protein hCdc4 of the F-box protein in humans in a breast cancer cell line is discussed.
Publication Name: Nature
Subject: Zoology and wildlife conservation
ISSN: 0028-0836
Year: 2001
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