Different beta-subunits determine G-protein interaction with transmembrane receptors
Article Abstract:
The regulatory GTP-binding proteins (G proteins) consist of alpha, beta and gamma membrane-attached heterotrimer subunits. The beta-1 and beta-3 subtypes have now been shown to help control the signal transduction cascade from muscarinic M4 and somatostatin receptors to voltage-dependent calcium 2+ channels. Discovery of the beta subunits' role in inducing G-protein to react with transmembrane receptors is the first significant progress in establishing the subunits' physiological function.
Publication Name: Nature
Subject: Zoology and wildlife conservation
ISSN: 0028-0836
Year: 1992
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Association between GTPase activators for Rho and Ras families
Article Abstract:
The recombinant p190 protein resembles the GTPase activating proteins (GAPs) most particularly in acting as a GAP rho protein. This finding was obtained by performing GAP assays on 14 purified GTPases. Hence the formation of a complex involving the Ras-GAP and p190 in growth-factor simulated cells may permit the coupling of signalling pathways with the ras and rho GTPases. The GAP activity of p190 results from DNA sequences common to the breakpoint cluster region.
Publication Name: Nature
Subject: Zoology and wildlife conservation
ISSN: 0028-0836
Year: 1992
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C5L2 is critical for the biological activities of the anaphylatoxins C5a and C3a
Article Abstract:
Experiment shows that G-protein-coupled receptor (GPCR) C5L2 is required for effective modulation of C5a and C3a for anaphylatoxin induced responses and its deficiency affects anti-inflammatory responses.
Publication Name: Nature
Subject: Zoology and wildlife conservation
ISSN: 0028-0836
Year: 2007
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