Dimeric ligands define a role for transcriptional activation domains in reinitiation
Article Abstract:
Homodimeric and heterodimerizing synthetic ligands may be used as transcriptional switches to regulate the transcription, in vitro and in vivo, for both therapeutic and experimental applications. These dimers permit ligand-dependent association and disassociation of a transcriptional activation domain with a promoter. The continued presence of a transcriptional activation domain is necessary to maintain the transcription of endogenous genes in vivo, in both mammalian and yeast cells.
Publication Name: Nature
Subject: Zoology and wildlife conservation
ISSN: 0028-0836
Year: 1996
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Unusual Rel-like architecture in the DNA-binding domain of the transcription factor NFATc
Article Abstract:
A 20K domain of NFATc needed to bind DNA and mobilize transcription has been identified. The two proteins use significantly different strategies for DNA recognition despite the relation between the overall folds of the NFATc DNA-binding protein and NF-kB p50. Both structures exhibit differences in the length and conformation of the segments which link these strands. NFAT and Rel proteins have been found to have a high sequence similarity.
Publication Name: Nature
Subject: Zoology and wildlife conservation
ISSN: 0028-0836
Year: 1997
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Rapid shuttling of NF-AT in discrimination of Ca2+ signals and immunosuppression
Article Abstract:
Sustained high concentrations of Ca2+ enable maintenance of nuclear localization of NF-AT transcription factors. The factors are involved in Ca2+ -dependent induction of genes necessary for lymphocyte activation and proliferation. However, immunosuppressive reagents, such as cyclosporin and FK506, block the subcellular localization of NF-AT family of transcription factors.
Publication Name: Nature
Subject: Zoology and wildlife conservation
ISSN: 0028-0836
Year: 1996
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