Distinct functions of nuclear and cytoplasmic calcium in the control of gene expression
Article Abstract:
Nuclear microinjection of a non-diffusible calcium chelator was made to impede increases in nuclear, but not cytoplasmic, calcium concentrations following activation of L-type voltage-gated calcium channels. This was done to show that gene expression is controlled by nuclear and cytoplasmic calcium signals which allow a single second messenger to generate diverse transcriptional responses. Results further showed that increased nuclear calcium concentration control calcium-activated gene expression mediated by the cyclic-AMP-response element. A second signaling pathway results from a rise in cytoplasmic calcium and does not require more nuclear calcium.
Publication Name: Nature
Subject: Zoology and wildlife conservation
ISSN: 0028-0836
Year: 1997
User Contributions:
Comment about this article or add new information about this topic:
Guides to 95 new angles
Article Abstract:
Pseudouridine, otherwise known as psi, is a modified nucleoside found on eukaryotic ribosomal ribonucleic acid. Research indicates that around 95 psi residues exist on the human ribosome. It is formed when psi synthase enzyme catalyzes a reaction involving the uracil base of the chromosome. Evidence suggests that an unpaired nucleotide sequence allows the psi enzyme into the double helix structure to perform its function.
Publication Name: Nature
Subject: Zoology and wildlife conservation
ISSN: 0028-0836
Year: 1997
User Contributions:
Comment about this article or add new information about this topic:
- Abstracts: Distribution of caribou and wolves in relation to linear corridors. Antler loss and udder distention in relation to parturition in caribou
- Abstracts: Manipulation of an atomic beam by a computer-generated hologram. Holography with X-rays
- Abstracts: Orbital modulation of the Earth's magnetic field intensity. Large-scale magnetic fields in the outflow from the young stellar object T Tauri S
- Abstracts: Seismicity and stress rotation in a granular model of the brittle crust. Long-period volcano seismicity: its source and use in eruption forecasting