Dorsoventral lineage restriction in wing imaginal discs requires Notch
Article Abstract:
It has been found that some or all of the requirement for apterous (ap) in establishing the dorsoventral lineage restriction in Drosophila could be mediated by its impact on Notch signalling. It is possible that Apterous drives affinity in a manner unconnected with signalling. It is suggested that there are three states of affinity: a dorsal, boundary-specific affinity state 'D,' a ventral, boundary-specific affinity state 'V' and a default affinity state 'X.' The clonal inheritance of ap expression prevents cells from switching between states D and V.
Publication Name: Nature
Subject: Zoology and wildlife conservation
ISSN: 0028-0836
Year: 1999
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Hedgehog digs up an old friend
Article Abstract:
Studies of the mode of action of Drosophila protein Hedgehog (Hh) reveal that reception of the Hh signal depends on protein kinase A (PKA), the main intracellular sensor for the second messenger cyclic AMP. Analysis of the role of Hh in two post-embryonic events shows that the loss of the PKA catalytic subunit in Drosophila forms a phenotype that is similar to but independent of the Hh signal reception.
Publication Name: Nature
Subject: Zoology and wildlife conservation
ISSN: 0028-0836
Year: 1995
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Boundary lines
Article Abstract:
Drosophila melanogaster is an elegant solution for the mechanism that accomplishes the simplification of tissue structures in multicellular organisms. In this simplification mechanism, the cells are lined in the surfaces of the body and divides into large compartments.
Publication Name: Nature
Subject: Zoology and wildlife conservation
ISSN: 0028-0836
Year: 2003
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