Elastic properties of DNA revealed
Article Abstract:
An effective way to measure the elastic properties of the DNA molecule involves a technique which was designed for straightening molecules of DNA turns. The adapted method involves anchoring the DNA's end molecules and stretching the strand by slowly withdrawing a liquid environment, using the retreating meniscus to pull the DNA. The measurement of the shape left by a doubly anchored molecule is made possible by the affinity of stranded DNA for the underlying surface.
Publication Name: Nature
Subject: Zoology and wildlife conservation
ISSN: 0028-0836
Year: 1995
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Reading the minor groove
Article Abstract:
It has been possible to describe a molecular code for the recognition of the four Watson-Crick base pairs from the minor groove of DNA using hairpin polyamides containing imidazole, pyrrole and 3-hydroxypyrrole rings. It was found that replacing the C(3)H group of pyrrole by a bulkier C(3)OH group allows hairpin polyamides to recognize all four base pairs. There is still little information about the behaviour of hairpin polyamides in a cellular environment.
Publication Name: Nature
Subject: Zoology and wildlife conservation
ISSN: 0028-0836
Year: 1998
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