Erythroid transcription factor GATA-1 is abundantly transcribed in mouse testis
Article Abstract:
The transcription factor GATA-1 was initially described as a genetic regulator in hematopoietic cells. Erythroid GATA-1 probes were used to analyze tissues from a 5-week-old mouse, resulting in the identification of a GATA-1 like transcript in testis tissue. The erythroid and testis GATA-1 transcripts are encoded by the same gene but are differentially transcribed and spliced. Cytological analysis showed that GATA-1-expressing cells in 10-week-old testis were in contact with the basement membrane of the seminiferous tubules, indicating that GATA-1 functions during the early stages of spermatogenesis.
Publication Name: Nature
Subject: Zoology and wildlife conservation
ISSN: 0028-0836
Year: 1993
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The Ras-MAPK pathway is important for olfaction in Caenorhabditis elegans
Article Abstract:
The activity of the Ras-mitogen-activated protein kinase (MAPK) pathway in mature olfactory neurons is significant for chemotaxis to AWC-sensed odorants. This research assessed the activity of the Ras-MAPK pathway directly by using a monoclonal antibody to activated (diphosphorylated) MAPK. It was possible to produce the first evidence that the Ras-MAPK pathway operates in the nervous system of Caenorhabditis elegans. It is clear that both hyperactivation and inactivation of the pathway impairs chemotaxis.
Publication Name: Nature
Subject: Zoology and wildlife conservation
ISSN: 0028-0836
Year: 2000
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Phosphorylation of RNA-binding protein controls cell cycle switch from mitotic to meiotic in fission yeast
Article Abstract:
RNA-binding protein Mei2 is a substrate of the Pat 1 kinase which is involved in the initiation and execution of meiosis. The mechanism of dephosphorylation of Mei2 is enough to switch the cells from mitosis to meiotic cell cycle. In the fission yeast Schizosaccharomyces pombe, protein kinase inactivation upon deprivation of nutrition has initiated its entrance into the meiotic cell cycle as shown in this experiment.
Publication Name: Nature
Subject: Zoology and wildlife conservation
ISSN: 0028-0836
Year: 1997
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