Essential flexibility in the T-cell recognition of antigen
Article Abstract:
An important part of the development of T cells is their capacity to respond productively to suboptimal ligands. T cells recognize an antigen on the surface of antigen presenting cell but the recognition of altered ligands causes partial activation. The response of the T-cell depends upon the ligand being recognized and the recognition helps in the generation of anticipatory immune systems. Small modifications within the peptide-MHC ligand results in partial T-cell activation, leading to both beneficial and harmful outcomes.
Publication Name: Nature
Subject: Zoology and wildlife conservation
ISSN: 0028-0836
Year: 1996
User Contributions:
Comment about this article or add new information about this topic:
Dual personality of memory T cells
Article Abstract:
It has been established that the chemokine receptor CCR7, a newly discovered cell-surface marker, is capable of distinguishing between two subsets of T cells that carry immunological memory. These two subsets appear to circulate around the body by different pathways, with the memory response being mediated in different ways. It is suggested that the naive T cell differentiates to a central memory T cell and, finally, to an effector memory cell.
Publication Name: Nature
Subject: Zoology and wildlife conservation
ISSN: 0028-0836
Year: 1999
User Contributions:
Comment about this article or add new information about this topic:
T cells and tumours
Article Abstract:
Issues are presented concerning the different response of the immune system to tumours which occur a different locations of the body. The response of the immune system to cancerous cells is discussed.
Publication Name: Nature
Subject: Zoology and wildlife conservation
ISSN: 0028-0836
Year: 2001
User Contributions:
Comment about this article or add new information about this topic:
- Abstracts: Essential role for Gab2 in the allergic response. Phosphorus solubilization in rewetted soils. Pasteur's quadrant and malnutrition
- Abstracts: Direct oxidation of hydrocarbons in a solid-oxide fuel cell. Is it all just a pipe dream?
- Abstracts: At grips with interactions. Induction of T-cell anergy by altered T-cell receptor ligand on live antigen-presenting cells
- Abstracts: A general boundary condition for liquid flow at solid surfaces. Liquid marbles
- Abstracts: Imaging the nonlinear grating in frequency-doubling fibres. Surgery by sunlight on live animals. A bottleneck for optical fibers