Essential role of the posterior morphogen nanos for germline development in Drosophila
Article Abstract:
The nanos (nos) protein is necessary for germline formation in Drosophila. Pole cells without nanos activity are unable to move into the gonads in the embryonic development of the abdominal portion of Drosophila, rendering them incapable of acting as functional germ cells. The lack of nanos activity leads to the abnormal development of pole cells, as marker genes generally expressed in pole cells in the gonads are activated prematurely. Regulatory factors involved in the activation of late pole-cell markers are probably contained in pole cells as mRNA whose translation is suppressed by nos protein.
Publication Name: Nature
Subject: Zoology and wildlife conservation
ISSN: 0028-0836
Year: 1996
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Calcium oscillations increase the efficiency and specificity of gene expression
Article Abstract:
Cytosolic calcium oscillations are a method of signalling in excitable and non-excitable cells, but it is unknown whether they contribute to the efficiency or specificity of signalling. A Ca(super2+) clamp technique was used to examine the roles of oscillation amplitude and frequency in gene expression regulation, driven by proinflammatory transcription factors NF-AT, Oct/OAP and NF-KB. Oscillations were found to reduce the effective Ca(super2+) threshold, thus increasing signal detection.
Publication Name: Nature
Subject: Zoology and wildlife conservation
ISSN: 0028-0836
Year: 1998
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Direct and continuous assessment by cells of their position in a morphogen gradient
Article Abstract:
Blastula tissue containing activin-loaded beads showed that cells responded directly and continuously to changing morphogen concentrations. The cells showed different gene expressions three hours after exposure to activin and 15 hours after exposure suggesting that cells use direct interaction to determine their responses to morphogen concentrations, resulting in expression changes when the concentration is modified.
Publication Name: Nature
Subject: Zoology and wildlife conservation
ISSN: 0028-0836
Year: 1995
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