Evidence for evolutionary conservation of sex-determining genes

Article Abstract:

Metazoans mostly occur as two sexes, and most molecular analyses have indicted that sex-determining mechanism differ between phyla. However evidence is provided to the contrary. The male sexual regulatory gene mab-3 was isolated from Caenorhabditis elegans, a nematode, and a relationship with the Dorsophila melenogaster sexual regulatory gene doublsex (dsx) was found. Both encode proteins having a DNA-binding motif, the DM domain, and both regulate sex-specific neuroblast differentiation and yolk protein gene transcription. A human gene DMT1, was found to only be expressed in testis, encoding a protein with a DM domain.

Observations, Nematoda, Nematodes, Sex determination, Genetic, Sex determination (Genetics)

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MRT-2 checkpoint protein is required for germline immortality and telomere replication in C. elegans

Article Abstract:

It is possible to address the problems of telomere maintenance and germline immortality by using an unbiased forward genetic approach in the nematode Caernorhabditis elegans. It has been established that a deficiency for a single DNA damage checkpoint protein can lead to a telomerase-negative phenotype in vivo. This finding has implications for genome stability in germline and somatic cells of other higher eukaryotes. It is possible that checkpoint proteins recognize telomeres as a special sort of DNA damage and actively recruit telomerase for repair.

Telomeres

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A view of Mount Drosophila

Article Abstract:

Rubin and colleagues have compared three eukaryotic genomes. They show that two animal genomes share many features not found in yeast.

Genomes, Drosophila

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