Facioscapulohumeral muscular dystrophy in mice overexpressing FRG1
Article Abstract:
Transgenic mice selectively overexpressing in skeletal muscle the 4q35 genes FRG1, FRG2 or ANT1 are generated to identify the gene responsible for facioscapulohumeral muscular dystrophy (FSHD) pathogenesis. It is found that FRG1 transgenic mice develop a muscular dystrophy while FRG2 and ANT1 mice seem normal, suggesting that FSHD results from inappropriate overexpression of FRG1 in skeletal muscle, leading to abnormal alternative splicing of specific pre-mRNAs.
Publication Name: Nature
Subject: Zoology and wildlife conservation
ISSN: 0028-0836
Year: 2006
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An elaborate pathway required for Ras-mediated epigenetic silencing
Article Abstract:
Studies are conducted to identify the genes required for Ras-mediated epigenetic silencing of the pro-apoptotic Fas gene. The findings reveal that nine Ras epigenetic silencing effectors are required for anchorage-independent growth and tumorigenicity of K-ras-transformed NIH 3T3 cells.
Publication Name: Nature
Subject: Zoology and wildlife conservation
ISSN: 0028-0836
Year: 2007
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Initiation of zebrafish haematopoiesis by the TATA-box-binding protein-related factor Trf3
Article Abstract:
The ability of the TATA-box binding protein (TBP)-related factor 3, Trf3 to initiate the zebrafish haematopoiesis is discussed.
Publication Name: Nature
Subject: Zoology and wildlife conservation
ISSN: 0028-0836
Year: 2007
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