Fools rush in
Article Abstract:
A model of the cell-division cycle has emerged where protein complexes regulate progression and checkpoints exist to monitor the replication status of the genetic material. Chan and colleagues have reported how the checkpoints interact with cyclin/CDk complexes to block the cell cycle. They disrupted the gene encoding 14-3-3delta in a human colorectal cancer cell line containing functional p53. Cells arrested in the G2 phase of the cell cycle after DNA damage, suggesting that the G2 DNA-damage checkpoint was intact, although the cells did not maintain cell-cycle arrest.
Publication Name: Nature
Subject: Zoology and wildlife conservation
ISSN: 0028-0836
Year: 1999
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Bid-deficient mice are resistant to FAs-induced hepatocellular apoptosis
Article Abstract:
The Bid protein participates in the pathway leading to cell death (apoptosis), mediating cytochrome c release from mitochondria. Mice deficient for Bid were generated, and when injected with an antibody directed against Fas, they survived and showed no apparent liver injury and no evidence of activation of effector caspases three and seven. Bid is believed to be an essential substrate in vivo for signalling by death-receptor agonists.
Publication Name: Nature
Subject: Zoology and wildlife conservation
ISSN: 0028-0836
Year: 1999
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