Form and function instructions
Article Abstract:
A study is conducted to demonstrate that maintaining the conservation pattern in a protein family, along with a small subset of coevolving residues, enables the generation of low-homology sequences that fold and function. The study indicates that the number of crucial interactions in a protein may be smaller than previously thought, a boon for those who want to design novel proteins from their inception to fulfill a specific function.
Publication Name: Nature
Subject: Zoology and wildlife conservation
ISSN: 0028-0836
Year: 2005
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Context-dependent contributions of backbone hydrogen bonding to beta-sheet folding energetics
Article Abstract:
The contribution of backbone H-bonds to the folding kinetics and thermodynamics of the PIN WW domain, a small beta-sheet protein, is assessed by individually replacing its backbone amides with esters. Results reveal an unusually elaborate picture of the folding of a beta-sheet protein.
Publication Name: Nature
Subject: Zoology and wildlife conservation
ISSN: 0028-0836
Year: 2004
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Folding at the speed limit
Article Abstract:
Rapidly folding mutant of the five-helix bundle protein lamda6-85 is studied to find molecular timescale and speed limit of folding. Molecular time scale represents the natural pre-factor for transition state models of folding.
Publication Name: Nature
Subject: Zoology and wildlife conservation
ISSN: 0028-0836
Year: 2003
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