Function of 14-3-3 proteins
Article Abstract:
The human 14-3-3-epsilon cDNA is found in the 8-1 probe, which has been used to define the 5' end of the Miller-Dieker chromosomal region (MDCR) locus. The recombinants for this gene in mammalian 88 progeny show that these genes are separated by 0-3.3 centimorgan. The 8-1 probe is chimeric for more than 1 gene. The 14-3-3 proteins are acidic proteins in the brain, which also act as multifunctional regulators involved in the cell-cycle control and a number of signal transduction pathways. They interact with cellular and viral oncoproteins.
Publication Name: Nature
Subject: Zoology and wildlife conservation
ISSN: 0028-0836
Year: 1996
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Crystal structure of colicin Ia
Article Abstract:
Colicin Ia and other ion-channel forming colicins destroy bacterial cells selectively. In the same manner as colicins A, B, E1, Ib and N, colicin Ia achieves this by taking over bacterial active-transport pathways and creating voltage-gated ion conducting channels across the target bacterium's plasma membrane. The crystal structure of colicin Ia shows a molecule 210 A long with three domains that have different functions in building conducting channels across the target cell.
Publication Name: Nature
Subject: Zoology and wildlife conservation
ISSN: 0028-0836
Year: 1997
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Ca2+ - and calcineurin-dependent recycling of an integrin to the front of migrating neutrophils
Article Abstract:
The recycling of alpha-v-beta-3 integrins to the front of migrating cells, is required for migration of the cells to continue in vitronectin. The migration of neutrophils is induced by chemoattractants that activate the signalling pathways and the neutrophils send out pseudopods to facilitate migration. The number of alpha-v-beta-3 integrins is higher at the leading edge than in the rear end, in neutrophils that migrate in vitronectin.
Publication Name: Nature
Subject: Zoology and wildlife conservation
ISSN: 0028-0836
Year: 1995
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