Gene therapy - promises, problems and prospects
Article Abstract:
The promise of gene therapy for alleviating the symptoms of disease is not being fulfilled in practice. Gene therapy involves identifying DNA sequences and cell types, and putting DNA into these cells. However, the 200-plus clinical trials of the concept have revealed problems, including host immune responses and a lack of efficient delivery systems. Scientists now need to re-examine the basic science behind the approach, particularly the interdependent aspects of cell biology, immunology and vectors, to ensure that the therapy fulfills its promise. An analysis of genetic vectors is presented.
Publication Name: Nature
Subject: Zoology and wildlife conservation
ISSN: 0028-0836
Year: 1997
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Glyoxalase 1 and glutathione reductase 1 regulate anxiety in mice
Article Abstract:
Anxiety and fear are emotional responses which are normal and there are anxiety disorders such as panic disorder, obsessive compulsive disorder, post traumatic stress disorder, social phobia, specific phobias and generalized anxiety disorder where the responses are exaggerated. The genetic manipulation is performed to determine if two of the genes glyoxalase 1 and glutathione reductase 1 have a causal role in the genesis of anxiety and genetic manipulation is performed using lentivirus mediated gene transfer.
Publication Name: Nature
Subject: Zoology and wildlife conservation
ISSN: 0028-0836
Year: 2005
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Therapeutic gene causing lymphoma
Article Abstract:
The gene therapy trials for X-linked severe combined immune deficiency (X-SCID), are based on the assumption that gamma-chain of the interleukin-2 receptor (IL2RG) is minimally oncogenic and may therefore pose some risk to patients. The development of leukemia after the gene therapy has attributed to the upregulated expression of the oncogene LMO2 as a result of vector integration.
Publication Name: Nature
Subject: Zoology and wildlife conservation
ISSN: 0028-0836
Year: 2006
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