Genetic ablation reveals that the roof plate is essential for dorsal interneuron specification

Article Abstract:

The loss of the roof plate in mice in which the roof plate has been selectively ablated by toxin gene expression is linked with failure to produce almost all of the neuronal classes that are usually produced in the dorsal region of the neural tube. It is clear that the epidermal ectoderm and roof plate have distinct roles in the control of the dorsal neural pattern. It is suggested that cascades of inductive signalling could involve sequentially acting organizers. Each of these organizers has a specific part in the promotion of cell diversity during vertebrate embryogenesis.

Abnormalities, Neural tube, Vertebrae, Thoracic, Thoracic vertebrae, Neural tube defects

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The zebrafish organizer requires chordino

Article Abstract:

Research shows that the zebrafish embryo requires the presence of chordino during early dorsoventral organization. Chordino's function is to act as an antagonist of ventralizing bone morphogenetic proteins, supporting the idea that mechanisms of early dorsoventral patterning are conserved between invertebrates and vertebrates.

Observations, Neurobiology, Cell research, Cytological research, Danio

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Motor neuron columnar fate imposed by sequential phases of hox-c activity

Article Abstract:

Sequential phases of Hox-c protein expression and activity control the columnar differentiation of spinal motor neurons are mentioned. Hox expression in neural progenitors is established by graded fibroblast growth factor signaling and translated into a distinct motor protein expression neuron Hox pattern.

Science & research, Motor neurons, Central nervous system, Structure

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