Genetic enhancement of learning and memory in mice
Article Abstract:
The N-methyl-D-aspartate (NMDA) receptor acts as a graded molecular switch for gating the age-dependent threshold for synaptic plasticity and memory function in mice. This finding provides strong confirmation for Hebb's learning rule. It was established that overexpression of NMDA receptor 2B in the forebrains of transgenic mice induces enhanced activation of NMDA receptors. This allows synaptic potentiation in response to stimulation at 10 Hz to 100 Hz. Neural activities at this range in the forebrain could be essential for coding and storing learned information.
Publication Name: Nature
Subject: Zoology and wildlife conservation
ISSN: 0028-0836
Year: 1999
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Targets of the cyclin-dependent kinase Cdk1
Article Abstract:
Cyclin-dependent kinases (Cdks) control the cell cycle by catalyzing the transfer of phosphate from ATP to specific protein substrates. Detailed analysis of the Cdk1 substrates are provided which are likely to yield important insights into cell-cycle regulation.
Publication Name: Nature
Subject: Zoology and wildlife conservation
ISSN: 0028-0836
Year: 2003
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A chemical switch for inhibitor-sensitive alleles of any protein kinase
Article Abstract:
Research is presented concerning the difficulties of developing a technique for the inhibition of protein kinases through specific inhibitors. A chemical genetic strategy to overcome this difficulty is discussed.
Publication Name: Nature
Subject: Zoology and wildlife conservation
ISSN: 0028-0836
Year: 2000
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