Histone arginine methylation regulates pluripotency in the early mouse embryo
Article Abstract:
Research shows that the cells present in mouse embryo can be different in their developmental fate and potency as early as the four-cell stage depending on the orientation and order of the cleavage divisions that generated them. The cells fate and potency are correlated with the modification of histone H3, through the methylation of specific arginine residues and the levels of H3 methylation are maximal in four-cell blastomeres that contribute to the inner cell mass and polar trophectoderm.
Publication Name: Nature
Subject: Zoology and wildlife conservation
ISSN: 0028-0836
Year: 2007
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The first cleavage of the mouse zygote predicts the blast cyst axis
Article Abstract:
The importance of the orientation of the first cleavage of the mouse zygote was tested after an elongated shape was imposed on it. Non-invasive lineage tracing shows that the progeny of the resulting two-cell blastomeres tend to populate the respective embryonic and abembryonic parts of the blastocyst, thus, the first cleavage contributes to breaking the symmetry of the embryo.
Publication Name: Nature
Subject: Zoology and wildlife conservation
ISSN: 0028-0836
Year: 2005
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Role for sperm in spatial patterning of the early mouse embryo
Article Abstract:
Research is presented concerning the influence of the entry position of sperm in the prediction of the initial cleavage plane of a mouse egg. The implications for the identity of cells are discussed.
Publication Name: Nature
Subject: Zoology and wildlife conservation
ISSN: 0028-0836
Year: 2001
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