Human herpesvirus KSHV encodes a constitutively active G-protein-coupled receptor linked to cell proliferation
Article Abstract:
The Kaposi's sarcoma-associated herpesvirus G-protein-coupled receptor, a virus which is always present in AIDS-related malignancies, is a fully active signalling receptor in the absence of chemokine ligands. It can activate a mitogenic signalling pathway involving phosphoinositide-specific phospholipase C by activating a G protein. Its constitutive activity can be compared to maximal agonist-dependent activity for CXCR2. It is proposed as a viral oncogene as it stimulates cellular proliferation.
Publication Name: Nature
Subject: Zoology and wildlife conservation
ISSN: 0028-0836
Year: 1997
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Transformation of primary human endothelian cells by Kaposi's sarcoma-associated herpesvirus
Article Abstract:
Infecting human primary endothelial cells with purified Kaposi's sarcoma-associated herpesvirus (KSHV) particles leads to long-term proliferation and survival of these cells. The cells' survival could be mediated by upregulation of a receptor for vascular endothelial growth factor. KSHV uses a paracrine mechanism to allow uninfected cells in the same culture to proliferate beyond their natural lifespan. It is required for growth in soft agar, where all colonies contain the viral genome.
Publication Name: Nature
Subject: Zoology and wildlife conservation
ISSN: 0028-0836
Year: 1998
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G-protein-coupled receptor of Kaposi's sarcoma-associated herpesvirus is a viral oncogene and angiogenesis activator
Article Abstract:
The Kaposi's sarcoma-associated herpesvirus is implicated in the pathogenesis of Kaposi's sarcoma and of primary effusion B-cell lymphomas (PELs). It is shown that KSHV G-protein-coupled receptor signalling, leads to cell transformation and tumor-igenicity, causing a switch to an angiogenic phenotype. It is concluded that the KSHV G-protein-coupled receptor is a viral oncogene.
Publication Name: Nature
Subject: Zoology and wildlife conservation
ISSN: 0028-0836
Year: 1998
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