ICOS co-stimulatory receptor is essential for T-cell activation and function
Article Abstract:
A new study investigates the role of the inductible co-stimulatory molecule (ICOS) in T-cell activation and function in animals.
Publication Name: Nature
Subject: Zoology and wildlife conservation
ISSN: 0028-0836
Year: 2001
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ICOS is critical for CD40-mediated antibody class switching
Article Abstract:
A new study investigates the functions of the inducible co-stimulatory molecule (ICOS) in regulating T cell differentiation in mice lacking ICOS.
Publication Name: Nature
Subject: Zoology and wildlife conservation
ISSN: 0028-0836
Year: 2001
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Impairment of antigen-specific T-cell priming in mice lacking CD40 ligand
Article Abstract:
A study has been conducted to determine whether expression of the CD40 ligand influences T-cell responsiveness by comparing the responses of CD40L-deficient and wild-type mice immunized with a protein antigen. Mice cells lacking CD40 failed to evoke cell responses upon antigen challenge, suggesting an impaired humoral immune response. An analysis of the naive CD40-deficient cells in normal and mutant mice showed that CD40 L expression is required for the priming of CD4+ T cells, which are needed for initiating specific T-cell immune responses.
Publication Name: Nature
Subject: Zoology and wildlife conservation
ISSN: 0028-0836
Year: 1995
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