Identification of a functional intermediate in receptor activation in progesterone-dependent cell-free transcription

Article Abstract:

Breast cancer cells have been shown to be rich in the hormone progesterone (PG) and receptors for this hormone. The progesterone receptors (PR) are present in significant numbers even in the absence of the hormone itself. Breast cancer cells were grown under PG-deprived conditions to test what the genetic material (DNA, deoxyribonucleic acid) of the cell would do under various circumstances. When the researchers incubated these cells with progesterone, specific DNA-protein complexes were formed. This transcription activity did not occur without the hormone progesterone, and occurred concurrently with specific progesterone response elements (PRE) binding to the progesterone receptor, thus forming a PRE-driven promoter. These in vitro (in the laboratory) experiments show activity similar to that observed in vivo (in the body), and affirm that there is a two-step complex-mediated (or ligand-induced) activation of the progesterone receptor's activation of genetic transcription. (Consumer Summary produced by Reliance Medical Information, Inc.)

Physiological aspects, Breast cancer, Progesterone, Breast, Progesterone receptors

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Suppression of Notch signaling by the COUP-TFII transcription factor regulates vein identity

Article Abstract:

The study shows that COUP-TFII, a member of the orphan nuclear receptor superfamily, is specifically expressed in venous. It discusses that COUP-TFII has a critical role in repressing notch signaling to maintain vein identity, which suggest that vein identity is under genetic control and is not derived by a default pathway.

Genetic research

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A mechanosensory complex that mediates the endothelial cell response to fluid shear stress

Article Abstract:

Shear stress is transmitted from the apical surface of the endothelial cell through the cytoskeleton to points of attachment at cell-cell and cell-matrix adhesions. The endothelial contains adherens junctions that depend on vascular endothelial cell cadherin, and tight junctions involving claudins and occludins.

Cytoskeleton

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