Impairment of angiogenesis and cell migration by targeted aquaporin-1 gene disruption
Article Abstract:
Study conducted reveals a remarkably impaired tumour growth in Aquaporin-1 (AQP1)-null mice after subcutaneous or intracranial tumour cell implantation, with reduced tumour vascularity and extensive necrosis. The findings obtained from the study support a fundamental role of water channels in cell migration, which is central to diverse biological phenomena including angiogenesis, wound healing, tumour spread and organ regeneration.
Publication Name: Nature
Subject: Zoology and wildlife conservation
ISSN: 0028-0836
Year: 2005
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Structural mechanism of plant aquaporin gating
Article Abstract:
A study on how plants counteract fluctuations in water supply by regulating all aquaporins in the cell plasma membrane is illustrated. Members of the aquaporin family are found in archaea, eubacteria and eukaryotes, including fungi, animals and plants and serve an astonishing variety of physiological function and are easily identified by sequence similarity across all kingdoms of life.
Publication Name: Nature
Subject: Zoology and wildlife conservation
ISSN: 0028-0836
Year: 2006
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Aquaporin enters the picture
Article Abstract:
The aquaporins are a family of proteins that facilitate the movement of water across the cell membrane, and in some cases they also act as a channel for molecules such as glycerol and other small solutes. Aquaporin-7 is one such channel and its synthesis in fat cells is sensitive to various stimuli, including fasting and insulin thus controlling fat metabolism.
Publication Name: Nature
Subject: Zoology and wildlife conservation
ISSN: 0028-0836
Year: 2005
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