Increased susceptibility to ultraviolet-B and carcinogens of mice lacking the DNA excision repair gene XPA
Article Abstract:
Group-A Xeroderma pigmentosum (XPA)-deficient mice show high vulnerability to ultraviolet-B-induced and 7,12-dimethylbenz-(a) anthracene (DMBA)-induced skin and eye carcinogenesis. These results reveal that XPA-deficient mice are excellent mimics of the human Xeroderma pigmentosum phenotype. The potential of XPA-deficient mice for studying the high rates of skin cancers due to ultraviolet radiation and chemical carcinogens is discussed.
Publication Name: Nature
Subject: Zoology and wildlife conservation
ISSN: 0028-0836
Year: 1995
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Cyclin-dependent kinases prevent DNA re-replication through multiple mechanisms
Article Abstract:
Research is presented concerning the influence of Saccharomyces cerevisiae kinases which are cyclin-dependent on the inhibition of DNA re-replication through several over-lapping mechanisms such as phosphorylation.
Publication Name: Nature
Subject: Zoology and wildlife conservation
ISSN: 0028-0836
Year: 2001
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Direct observation of hole transfer through DNA by hopping between adenine bases and by tunnelling
Article Abstract:
Research is presented concerning the measurement of the efficiency of the transfer of charge between guanines which are separated by double stranded adenine-thymine bridges of varying lengths in the DNA molecule.
Publication Name: Nature
Subject: Zoology and wildlife conservation
ISSN: 0028-0836
Year: 2001
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